Description

3-Chloro-5-Iodobenzonitrile is a versatile halogenated benzonitrile derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and iodo substituents on the aromatic ring, makes it a valuable scaffold for constructing complex molecules, particularly in pharmaceutical and agrochemical research. This compound is essential for medicinal chemists and process development scientists engaged in cross-coupling reactions and the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its halogenated aromatic core.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers and liquid crystals.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Sonogashira, and Buchwald-Hartwig amination reactions due to the reactive iodo and chloro groups.
• Ligand and Catalyst Development: Utilized in the preparation of specialized ligands for transition metal catalysis.
• Chemical Biology Probes: Acts as a starting material for synthesizing molecular probes and tags used in biochemical assays.

Basic Information

Item	Details
Product Name	3-Chloro-5-Iodobenzonitrile
CAS No.	289039-30-1
Molecular Formula	C7H3ClIN
Molecular Weight	263.46 g/mol
Synonyms	3-Chloro-5-iodobenzonitrile; 5-Chloro-3-iodobenzonitrile; 2-Chloro-6-cyanophenyl iodide; Benzonitrile, 3-chloro-5-iodo-; 3-Chloro-5-iodo-benzonitrile; 289039-30-1; 3-Cl-5-I-C6H3-CN
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Iodobenzonitrile is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, GC, NMR, and elemental analysis, to ensure identity, purity, and consistency. Certificates of Analysis (COA) documenting all critical parameters are provided and available upon request. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from incompatible materials such as strong bases and reducing agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.