Description

2-Chloro-5-Iodobenzonitrile is a versatile halogenated benzonitrile derivative that serves as a critical synthetic intermediate in advanced organic chemistry. Its unique structure, featuring both chloro and iodo substituents, makes it a valuable building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in drug discovery, material science, and the synthesis of functionalized aromatic systems.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules targeting central nervous system disorders and oncology.
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and plant growth regulators that require halogenated aromatic cores.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of organic semiconductors, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig amination due to the reactive iodo and chloro groups.
• Ligand and Catalyst Development: Employed in the synthesis of specialized phosphine or nitrogen-based ligands for asymmetric catalysis.
• Chemical Biology Probes: Used to create tagged molecules or irreversible inhibitors for studying enzyme mechanisms and protein function.

Basic Information

Product Name	2-Chloro-5-Iodobenzonitrile
CAS No.	289039-29-8
Molecular Formula	C7H3ClIN
Molecular Weight	263.46 g/mol
Synonyms	5-Iodo-2-chlorobenzonitrile; 2-Chloro-5-iodobenzene carbonitrile; Benzonitrile, 2-chloro-5-iodo-; 2-Chloro-5-iodo-benzonitrile; 2-Chloro-5-iodobenzonitrile (CAS 289039-29-8); 2-Chloro-5-iodobenzocarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-Chloro-5-Iodobenzonitrile is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for research and process chemistry. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles via HPLC, GC, NMR, and mass spectrometry is supplied with each shipment. Our quality commitment aligns with cGMP principles for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.