Description

Fmoc-Glu-Nh2 CAS NO 288149-55-3 is a protected glutamic acid derivative, specifically an Fmoc-protected glutamine analog, widely used as a critical building block in solid-phase peptide synthesis (SPPS). This high-purity amino acid derivative is essential for researchers and manufacturers requiring precise control over peptide chain assembly, particularly for introducing glutamic acid residues with orthogonal side-chain protection. It is a fundamental raw material for pharmaceutical R&D, biotechnology, and the production of therapeutic peptides and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key reagent for the sequential coupling of amino acids to construct peptides and small proteins.
• Pharmaceutical Intermediate: Used in the research and development of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Combinatorial Chemistry: Serves as a building block for creating diverse chemical libraries for drug discovery and screening.
• Bioconjugation: Employed in the site-specific modification of peptides and proteins for diagnostic or therapeutic purposes.
• Academic & Industrial Research: Fundamental material for studying peptide structure, function, and for developing novel synthetic methodologies.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.

Basic Information

Product Name	Fmoc-Glu-Nh2
CAS No.	288149-55-3
Molecular Formula	C₂₀H₂₀N₂O₅
Molecular Weight	368.38 g/mol
Synonyms	Fmoc-L-Glutamine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-glutamine; Fmoc-Gln-OH; Nα-Fmoc-L-glutamine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-5-amino-5-oxopentanoic acid; Fmoc-Glutamine; Fmoc-L-Gln-OH; N-Fmocglutamine
EINECS	Contact for details

Quality Control

Our Fmoc-Glu-Nh2 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, typically meeting standards suitable for peptide synthesis and pharmaceutical research. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We ensure compliance with relevant industry guidelines, and specifications can be tailored to meet specific project requirements for advanced R&D and GMP manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.