Description

(R)-4-Bromo-2-(Oxiran-2-Ylmethoxy)Benzonitrile is a high-purity chiral building block featuring a benzonitrile core substituted with a bromine atom and an epoxide-containing ether side chain. This compound is of significant value in pharmaceutical research and development, serving as a key intermediate for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries for constructing complex molecular architectures with precise stereochemistry.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the development of novel therapeutic agents, particularly in oncology and CNS drug discovery.
• Asymmetric Synthesis: Used in stereoselective reactions to introduce the (R)-configured epoxide moiety into target molecules.
• Agrochemical Research: Serves as a building block for creating enantiomerically pure herbicides, fungicides, or plant growth regulators.
• Ligand and Catalyst Development: A precursor for synthesizing chiral ligands or organocatalysts used in asymmetric catalysis.
• Material Science: Potential monomer or cross-linking agent for advanced polymers with specific optical or mechanical properties.
• Academic & Contract Research: Essential for methodological studies in organic and medicinal chemistry within academic and CRO (Contract Research Organization) settings.

Basic Information

Product Name	(R)-4-Bromo-2-(Oxiran-2-Ylmethoxy)Benzonitrile
CAS No.	288067-41-4
Molecular Formula	C11H10BrNO2
Molecular Weight	268.11 g/mol
Synonyms	(R)-4-Bromo-2-(2,3-Epoxypropoxy)benzonitrile; (R)-2-(Oxiran-2-ylmethoxy)-4-bromobenzonitrile; (R)-4-Bromo-2-[(oxiran-2-yl)methoxy]benzonitrile; (R)-4-Bromo-2-glycidyloxybenzonitrile; (R)-2-(Glycidyloxy)-4-bromobenzonitrile; 4-Bromo-2-[(2R)-oxiran-2-ylmethoxy]benzonitrile; (R)-Epichlorohydrin 4-bromo-2-cyanophenyl ether (precursor related); (R)-Bromophenyl glycidyl ether nitrile derivative
EINECS	Contact for details

Quality Control

Our (R)-4-Bromo-2-(Oxiran-2-Ylmethoxy)Benzonitrile is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification, to ensure compliance with exacting R&D and process chemistry standards. A comprehensive Certificate of Analysis (COA) detailing identity, purity (HPLC), chiral excess, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.