Description

2,2,2-Trifluoroethyl Crotonate is a specialized fluorinated ester building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the trifluoroethoxy group, which can enhance the lipophilicity and metabolic stability of target molecules. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for introducing the 2,2,2-trifluoroethoxy moiety into potential drug candidates, particularly in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and development of novel pesticides and herbicides, where the fluorine atoms can improve biological activity and environmental persistence.
• Polymer & Material Science: Serves as a monomer or modifier in the synthesis of specialty fluoropolymers, imparting unique surface properties, chemical resistance, and optical characteristics.
• Liquid Crystal & Electronic Materials: Employed in the development of fluorinated components for liquid crystal displays (LCDs) and other electronic applications due to its dielectric properties.
• Organic Synthesis Building Block: Utilized in Michael additions, radical reactions, and other C-C bond-forming transformations to create complex, fluorinated organic structures.
• Cross-coupling Reactions: Acts as a substrate in palladium-catalyzed reactions, such as Heck couplings, for the synthesis of styrene derivatives with fluorinated side chains.

Basic Information

Product Name	2,2,2-Trifluoroethyl Crotonate
CAS No.	287957-36-2
Molecular Formula	C7H7F3O2
Molecular Weight	180.12 g/mol
Synonyms	2,2,2-Trifluoroethyl (E)-but-2-enoate; Crotonic Acid 2,2,2-Trifluoroethyl Ester; (E)-2-Butenoic Acid 2,2,2-Trifluoroethyl Ester; 2,2,2-Trifluoroethyl trans-2-Butenoate; 2-Propenoic Acid, 2-Butenoic Acid, 2,2,2-Trifluoroethyl Ester; Trifluoroethyl Crotonate; TFEC
EINECS	Contact for details

Quality Control

Our 2,2,2-Trifluoroethyl Crotonate is produced and handled under strict quality management protocols. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) with detailed specifications are provided for each shipment, supporting your R&D and scale-up activities with reliable data.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong bases and oxidizing agents. Recommended storage temperature is between 2°C and 8°C for long-term stability. Allow the container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	Clear, colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (GC)	≥ 98.0%
Isomeric Purity (E/Z Ratio)	≥ 99:1 (E/Z)
Water Content (KF)	≤ 0.1%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.