Description

Gentamicin C1 Deuterated Pentaacetate Salt (>90%) is a high-purity, isotopically labeled derivative of the aminoglycoside antibiotic gentamicin C1. This compound is specifically designed for use as a critical internal standard in quantitative mass spectrometry, ensuring unparalleled accuracy and reliability in analytical workflows. It is an essential reagent for researchers and quality control laboratories in the pharmaceutical, biotechnology, and contract research organization (CRO) sectors who require precise quantification of gentamicin and its related substances.

Application

• LC-MS/MS Internal Standard: Primary application as a stable isotope-labeled internal standard for the precise quantification of Gentamicin C1 and related components in complex biological matrices (e.g., plasma, serum, tissue).
• Pharmacokinetic & Bioanalytical Studies: Enables accurate measurement of drug concentration-time profiles, supporting ADME (Absorption, Distribution, Metabolism, Excretion) studies and bioequivalence assessments.
• Veterinary Drug Residue Analysis: Used in regulatory testing and food safety programs to monitor gentamicin residues in meat, milk, and other animal-derived products.
• Pharmaceutical Quality Control: Supports method development and validation for the assay and impurity profiling of gentamicin sulfate active pharmaceutical ingredient (API) and finished drug products.
• Metabolomics & Biomarker Research: Facilitates targeted metabolomic analysis for studying microbial metabolism or host-pathogen interactions involving aminoglycosides.
• Clinical Toxicology & Therapeutic Drug Monitoring (TDM): Aids in the accurate measurement of gentamicin levels in patient samples to optimize dosing and minimize nephrotoxicity and ototoxicity risks.

Basic Information

Product Name	Gentamicin C1 Deuterated Pentaacetate Salt (>90%)
CAS No.	287730-69-2
Molecular Formula	C23H41D5N5O7 • (C2H3O2)5 or related salt form
Molecular Weight	Contact for details
Synonyms	Gentamicin C1-d5 Pentaacetate; Deuterated Gentamicin C1 Pentaacetate Salt; Gentamicin C1 (pentadeutero) pentaacetate; Gentamicin C1 Internal Standard; 2-Deoxystreptamine, O-3-deoxy-4-C-methyl-3-(methylamino)-β-L-arabinopyranosyl-(1→6)-O-[2,6-diamino-2,3,4,6-tetradeoxy-α-D-erythro-hexopyranosyl-(1→4)]-, 1-N-[4-amino-2-hydroxy-1-oxobutyl]-, pentaacetate, deuterated; Gentamicin C1-d5 Acetate Salt; Isotopically Labeled Gentamicin C1.
EINECS	Contact for details

Quality Control

Every batch of our Gentamicin C1 Deuterated Pentaacetate Salt (>90%) is manufactured and analyzed under strict quality management systems. The product undergoes rigorous testing, including advanced chromatographic and spectroscopic methods, to confirm isotopic enrichment (>90% deuterium), chemical purity, and identity. A comprehensive Certificate of Analysis (COA) detailing lot-specific results for assay, isotopic purity, and related substances is provided to ensure traceability and compliance with your research or quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a freezer. The product is hygroscopic (moisture-sensitive); allow the sealed vial to equilibrate to room temperature before opening to prevent condensation and moisture uptake. For long-term stability, store under inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (MS)	Conforms to expected mass
Purity (HPLC)	>90% (by area normalization)
Isotopic Enrichment (MS)	Min. 90 atom % D
Water Content (KF)	≤ 5.0 %
Residual Solvents (GC)	Complies with ICH limits

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.