Description

(2R)-2-{[(tert-Butoxy)Carbonyl](Methyl)Amino}-4,4-Dimethylpentanoic Acid is a high-purity, chiral N-Boc-protected amino acid derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in enabling the precise construction of complex molecules with defined stereochemistry, which is essential for developing bioactive compounds. This product is specifically designed for research and production in the pharmaceutical and fine chemical industries, where it is used to synthesize peptides, peptidomimetics, and other active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including protease inhibitors and other small molecule drugs.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to introduce sterically hindered, non-natural amino acid residues into peptide chains.
• Chemical Biology & Proteomics: Employed in the synthesis of specialized probes, inhibitors, and substrates for studying enzyme mechanisms and protein-protein interactions.
• Agrochemical Research: Acts as a building block for creating chiral active ingredients with potential herbicidal or insecticidal activity.
• Material Science: Can be utilized in the synthesis of functional polymers and dendrimers with specific chiral properties.
• Academic & Contract Research: A valuable reagent for universities and CROs (Contract Research Organizations) conducting research in asymmetric synthesis and medicinal chemistry.

Basic Information

Product Name	(2R)-2-{[(tert-Butoxy)Carbonyl](Methyl)Amino}-4,4-Dimethylpentanoic Acid
CAS No.	287210-83-7
Molecular Formula	C13H25NO4
Molecular Weight	259.34 g/mol
Synonyms	(R)-2-((tert-Butoxycarbonyl)(methyl)amino)-4,4-dimethylpentanoic acid; Boc-N-Me-D-tert-Leucine; N-Methyl-N-Boc-D-tert-leucine; (R)-2-[(tert-Butoxycarbonyl)(methyl)amino]-4,4-dimethylpentanoic acid; D-N-Methyl-tert-leucine N-Boc derivative; (2R)-2-[(tert-Butoxycarbonyl)(methyl)amino]-4,4-dimethylpentanoic acid; Boc-D-N-methyl-tert-leucine; N-Boc-N-methyl-D-tert-leucine
EINECS	Contact for details

Quality Control

Our (2R)-2-{[(tert-Butoxy)Carbonyl](Methyl)Amino}-4,4-Dimethylpentanoic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity research and pharmaceutical grade standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.