Description

3-Ethynyl-1-Azetidinecarboxylic Acid tert-Butyl Ester is a versatile and high-value azetidine-based building block. This compound is crucial for medicinal chemistry research and pharmaceutical development, serving as a key intermediate for constructing complex molecular architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to introduce the 3-ethynylazetidine pharmacophore, enabling the exploration of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in kinase inhibitor and protease inhibitor research.
• Medicinal Chemistry Scaffold: Used to introduce the constrained, three-membered azetidine ring with an alkyne handle for further functionalization via click chemistry (e.g., CuAAC).
• Proteolysis Targeting Chimera (PROTAC) Development: Serves as a linker component or a warhead attachment point in the design of bifunctional degraders.
• Agrochemical Research: Employed in the discovery and synthesis of new active ingredients with improved efficacy and selectivity.
• Chemical Biology Probes: Utilized to create labeled compounds for target identification and binding studies within biological systems.
• Material Science: Potential monomer or cross-linking agent for creating polymers with unique thermal or mechanical properties.

Basic Information

Product Name	3-Ethynyl-1-Azetidinecarboxylic Acid tert-Butyl Ester
CAS No.	287193-01-5
Molecular Formula	C10H15NO2
Molecular Weight	181.23 g/mol
Synonyms	1-Boc-3-ethynylazetidine; tert-Butyl 3-ethynylazetidine-1-carboxylate; 3-Ethynylazetidine-1-carboxylic acid tert-butyl ester; 1-N-Boc-3-ethynylazetidine; Azetidine-1-carboxylic acid, 3-ethynyl-, 1,1-dimethylethyl ester; Boc-3-ethynylazetidine; 3-Ethynyl-1-azetidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 3-Ethynyl-1-Azetidinecarboxylic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide a detailed Certificate of Analysis (COA) with every shipment, confirming compliance with customer specifications and supporting cGMP development requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to maintain stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0% (Area %)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.