Description

1-Pyrrolidinecarboxylic Acid, 3-Ethynyl-, 1,1-Dimethylethyl Ester is a high-value, specialized organic building block featuring a pyrrolidine core with an ethynyl substituent, protected by a tert-butyl ester group. This unique molecular architecture makes it a critical intermediate for constructing complex nitrogen-containing heterocycles and peptidomimetics in advanced synthetic chemistry. It is primarily sought after by pharmaceutical R&D and agrochemical research teams for developing novel active compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the synthesis of proline derivatives and constrained peptides in drug discovery programs.
• Agrochemical Research: Used in the development of novel herbicides and fungicides with targeted modes of action.
• Ligand Synthesis: Serves as a precursor for creating specialized ligands in catalysis and material science.
• Peptidomimetic Scaffolds: Integral for constructing conformationally restricted peptide analogs to enhance metabolic stability and bioavailability.
• Chemical Biology Probes: Utilized in the synthesis of tagged molecules for studying biological pathways and protein interactions.
• Academic & Industrial R&D: A versatile building block for methodological development and exploring new chemical space in organic synthesis.

Basic Information

Item	Details
Product Name	1-Pyrrolidinecarboxylic Acid, 3-Ethynyl-, 1,1-Dimethylethyl Ester
CAS No.	287193-00-4
Molecular Formula	C11H17NO2
Molecular Weight	195.26 g/mol
Synonyms	tert-Butyl 3-ethynylpyrrolidine-1-carboxylate; 1-Boc-3-ethynylpyrrolidine; 3-Ethynyl-1-Boc-pyrrolidine; 1-(tert-Butoxycarbonyl)-3-ethynylpyrrolidine; N-Boc-3-ethynylpyrrolidine; 3-Ethynylpyrrolidine-1-carboxylic acid tert-butyl ester; Boc-3-ethynylpyrrolidine; 3-Ethynyl-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our 1-Pyrrolidinecarboxylic Acid, 3-Ethynyl-, 1,1-Dimethylethyl Ester is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, identity, and impurity profiles. Our quality systems are designed to meet the stringent requirements of research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.