Description

1-Iodo-3-(Pentafluorosulfanyl)Benzene is a high-value, multi-functional fluorinated aromatic building block. This compound is prized for its unique combination of an iodine substituent and the highly electronegative pentafluorosulfanyl (SF5) group, which imparts exceptional stability and lipophilicity. It is primarily sought after by researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors for use in cross-coupling reactions, ligand synthesis, and the development of novel bioactive molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions for constructing complex biaryl structures in drug discovery.
• Agrochemical Synthesis: Used to introduce the SF5 moiety into lead compounds to enhance metabolic stability, bioavailability, and pesticidal activity.
• Ligand & Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis.
• Advanced Materials Research: Incorporated into organic semiconductors, liquid crystals, and high-performance polymers to tune electronic properties and thermal stability.
• Radiochemistry: The iodine atom provides a potential site for radioiodination (123I, 125I, 131I) for diagnostic and therapeutic applications.
• Chemical Biology Probes: Utilized in the synthesis of molecular probes and tags for studying biological systems and protein interactions.

Basic Information

Product Name	1-Iodo-3-(Pentafluorosulfanyl)Benzene
CAS No.	286947-67-9
Molecular Formula	C6H4F5IS
Molecular Weight	330.06 g/mol
Synonyms	3-Iodophenylsulfur pentafluoride; 3-Iodo-1-(pentafluorosulfanyl)benzene; 3-(Pentafluorosulfanyl)iodobenzene; 1-Iodo-3-(SF5)benzene; 3-Iodo-α,α,α,α',α',α'-hexafluorothioanisole; 3-Iodobenzene, 1-(pentafluorosulfanyl)-; (3-Iodophenyl)sulfur pentafluoride
EINECS	Contact for details

Quality Control

Every batch of 1-Iodo-3-(Pentafluorosulfanyl)Benzene is synthesized and purified under controlled conditions to ensure high chemical purity and lot-to-lot consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.