Description

Equilin-D4 is a high-purity, deuterium-labeled internal standard essential for precise quantitative analysis in mass spectrometry. This stable isotope-labeled compound is critical for ensuring analytical accuracy and reliability in complex matrices. It is primarily required by pharmaceutical research laboratories, contract research organizations (CROs), and analytical service providers for method development, validation, and bioanalytical studies.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in the bioanalysis of equilin and related equine estrogens in biological samples like plasma and serum.
• Pharmaceutical R&D: Facilitates pharmacokinetic (PK) and pharmacodynamic (PD) studies for hormone replacement therapy (HRT) drug development.
• Metabolite Identification: Aids in the detection and structural elucidation of drug metabolites in metabolism and excretion studies.
• Clinical Research: Enables accurate monitoring of drug levels in clinical trial samples for compliance and efficacy evaluation.
• Quality Control in Manufacturing: Serves as a critical component in the analytical methods used for the quality control of active pharmaceutical ingredients (APIs).
• Forensic and Doping Control: Employed in confirmatory testing for prohibited substances in equine and human sports.

Basic Information

Item	Details
Product Name	Equilin-D4
CAS No.	285979-79-5
Molecular Formula	C18H18D4O2
Molecular Weight	274.39 g/mol
Synonyms	3-Hydroxyestra-1,3,5(10),7-tetraen-17-one-d4; 1,3,5(10),7-Estratetraene-3-ol-17-one-d4; Equilin-2,4,16,16-d4; [2,4,16,16-2H4]-Equilin; Deuterated Equilin; Equilin-d4 (Internal Standard); Equilin (D4)
EINECS	Contact for details

Quality Control

Our Equilin-D4 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for chemical purity and NMR/MS for isotopic enrichment and structural confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific data on purity, isotopic purity, and solvent content. Our quality commitment ensures consistency and reliability for your most demanding analytical applications.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below. Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation. The product is hygroscopic (moisture-sensitive).

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.