Description

(1R,2R)-(-)-Pseudoephedrine-D3 Hcl (n-Methyl-D3) is a high-purity, deuterium-labeled internal standard critical for precise analytical quantification. This compound matters for ensuring the accuracy and reliability of mass spectrometry-based methods in pharmaceutical research and forensic analysis. It is primarily needed by analytical laboratories, pharmaceutical R&D teams, and forensic scientists for method development, validation, and quality control testing of pseudoephedrine and related compounds.

Application

• Internal Standard for LC-MS/MS: Used as a stable isotope-labeled internal standard for the precise quantification of pseudoephedrine in complex biological matrices like plasma, urine, and tissue homogenates.
• Pharmaceutical Metabolism Studies: Enables accurate tracking and measurement of pseudoephedrine and its metabolites in pharmacokinetic and ADME (Absorption, Distribution, Metabolism, Excretion) research.
• Forensic and Doping Control Analysis: Essential for confirmatory testing and high-accuracy measurement of pseudoephedrine in forensic toxicology and anti-doping programs.
• Method Development and Validation: Serves as a critical reference material for developing, optimizing, and validating robust analytical methods in compliance with regulatory guidelines (e.g., FDA, EMA).
• Quality Control in Pharmaceutical Manufacturing: Employed in in-process testing and final product release assays to ensure the purity and correct dosage of pseudoephedrine-containing pharmaceutical formulations.

Basic Information

Product Name	(1R,2R)-(-)-Pseudoephedrine-D3 Hcl (n-Methyl-D3)
CAS No.	285979-74-0
Molecular Formula	C10H12D3ClNO
Molecular Weight	203.72 g/mol
Synonyms	(1R,2R)-(-)-Pseudoephedrine-d3 hydrochloride; (1R,2S)-2-(Methyl-d3-amino)-1-phenylpropan-1-ol hydrochloride; Pseudoephedrine-d3 (N-methyl-d3) HCl; d3-Pseudoephedrine HCl; Deuterated Pseudoephedrine Internal Standard; PSE-d3 HCl; [2H3]-Pseudoephedrine hydrochloride
EINECS	Contact for details

Quality Control

Every batch of (1R,2R)-(-)-Pseudoephedrine-D3 Hcl (n-Methyl-D3) is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, supported by comprehensive analytical data including NMR, HPLC, and mass spectrometry. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity (typically ≥98% by HPLC), isotopic enrichment (typically ≥99 atom % D), and other critical specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity	≥ 99 atom % D
Chemical Purity	≥ 99% (by NMR)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.