Description

8-Trifluoromethyl-1,2,3,4-Tetrahydro-Isoquinoline is a high-value, fluorinated heterocyclic building block of significant interest in advanced organic synthesis. Its core value lies in the unique combination of the tetrahydroisoquinoline scaffold and the metabolically stable trifluoromethyl group, which is critical for modulating the physicochemical properties of target molecules. This compound is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the discovery and development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of central nervous system (CNS) agents, enzyme inhibitors, and other bioactive molecules.
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides, where the CF3 group enhances lipophilicity and biological activity.
• Material Science: Serves as a precursor for specialty chemicals and advanced materials, including liquid crystals and organic semiconductors.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization to improve drug-like properties such as metabolic stability and membrane permeability.
• Chemical Biology: Utilized as a probe or labeling agent in biochemical research due to its distinctive fluorine signature.
• Custom Synthesis: A versatile starting material for contract research organizations (CROs) and CDMOs serving the global life sciences market.

Basic Information

Product Name	8-Trifluoromethyl-1,2,3,4-Tetrahydro-Isoquinoline
CAS No.	284027-36-7
Molecular Formula	C10H10F3N
Molecular Weight	201.19 g/mol
Synonyms	8-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline; 1,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinoline; 8-Trifluoromethyl-1,2,3,4-tetrahydroisoquinoline; 8-CF3-THIQ; 8-Trifluoromethyl-THIQ; 284027-36-7; 8-Trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline
EINECS	Contact for details

Quality Control

Our 8-Trifluoromethyl-1,2,3,4-Tetrahydro-Isoquinoline is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure high purity and batch-to-batch consistency suitable for research and scale-up. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents. For long-term storage, consider an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.