Description

Ac-His-His-Gly-His-Nhme is a synthetic peptide derivative, specifically an acetylated tetrapeptide amide. This compound is of significant interest in biochemical and pharmaceutical research due to its structural mimicry of specific histidine-rich protein domains. It is primarily utilized by research institutions and biotechnology companies engaged in peptide synthesis, enzyme inhibition studies, and the development of novel therapeutic agents.

Application

• Biochemical Research: Used as a reference standard or substrate in enzymatic assays and protein interaction studies.
• Pharmaceutical R&D: Serves as a key intermediate or model compound in the development of peptide-based drugs and diagnostic tools.
• Enzyme Inhibition Studies: Investigated for its potential to modulate the activity of metalloenzymes, given its histidine-rich sequence.
• Peptide Synthesis: Employed as a building block for the solid-phase or solution-phase synthesis of larger, more complex polypeptides.
• Academic Research: Utilized in universities and laboratories for fundamental studies in bioinorganic chemistry and peptide science.

Basic Information

Product Name	Ac-His-His-Gly-His-Nhme
CAS No.	283167-53-3
Molecular Formula	C28H40N14O7
Molecular Weight	684.71 g/mol
Synonyms	Acetyl-His-His-Gly-His-NHMe; Ac-HHGH-NHMe; N-Acetyl-L-histidyl-L-histidylglycyl-L-histidine N-methylamide; Ac-His-His-Gly-His-Methylamide; L-Histidine, N-acetyl-L-histidyl-L-histidylglycyl-, N-methylamide; Ac-HHGH-NHCH3; Acetylhistidylhistidylglycylhistidine methylamide
EINECS	Contact for details

Quality Control

Our Ac-His-His-Gly-His-Nhme is produced under stringent quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification, mass spectrometry for identity confirmation, and amino acid analysis. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are provided to ensure compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms
Purity (HPLC)	≥ 95.0%
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 5.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.