Description

n-β-Fmoc-L-β-Glutamine is a specialized, orthogonally protected amino acid derivative designed for advanced solid-phase peptide synthesis (SPPS). This compound is essential for researchers and manufacturers requiring precise control over side-chain functionality during the construction of complex peptides and peptidomimetics. It is a critical building block for the pharmaceutical and biotechnology industries, particularly in the development of therapeutic peptides, diagnostic agents, and novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected glutamine analog for the controlled incorporation of the β-glutamine residue into peptide chains.
• Pharmaceutical Research: Building block for the synthesis of peptide-based drug candidates, including hormone analogs, enzyme inhibitors, and targeted therapeutics.
• Combinatorial Chemistry: Used in libraries for high-throughput screening to discover new bioactive molecules with optimized properties.
• Bioconjugation: Intermediate for creating peptide-protein or peptide-small molecule conjugates for drug delivery and diagnostic applications.
• Structural Biology Studies: Synthesis of custom peptides containing non-natural amino acids to study protein folding, function, and interactions.
• Process Development: Serves as a starting material for the scalable production of specific peptide sequences under GMP conditions.

Basic Information

Product Name	n-β-Fmoc-L-β-Glutamine
CAS No.	283160-18-9
Molecular Formula	C₂₀H₂₀N₂O₅
Molecular Weight	368.38 g/mol
Synonyms	Fmoc-β-Gln-OH; (2S)-5-Amino-2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-5-oxopentanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-β-glutamine; Fmoc-L-β-glutamine; N-β-Fmoc-L-β-glutamine; L-β-Glutamine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-; N-Fmoc-L-β-glutamine
EINECS	Contact for details

Quality Control

Our n-β-Fmoc-L-β-Glutamine is produced under strict quality management systems to ensure batch-to-batch consistency and high purity, typically ≥98% (HPLC). Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with relevant industry standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. Allow the container to reach room temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Specific Rotation	-20° to -25° (c=1, DMF)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.