Description

1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetamide, 2-[(4-Isothiocyanatophenyl)Methyl]- is a bifunctional chelating agent derivative of the macrocyclic DOTA ligand, engineered for the stable conjugation and complexation of metal ions. This compound is of critical importance for creating targeted diagnostic and therapeutic radiopharmaceuticals due to its high thermodynamic stability and kinetic inertness when bound to metals like gadolinium, lutetium, or yttrium. It is primarily needed by researchers and manufacturers in the pharmaceutical, biotechnology, and medical imaging sectors for developing next-generation contrast agents and radiolabeled therapeutics.

Application

• Radiopharmaceutical Precursor: Key intermediate for synthesizing targeted radiotherapeutics (e.g., for Lu-177, Y-90, Ac-225) used in cancer treatment.
• MRI Contrast Agent Development: Chelation site for Gadolinium (Gd³⁺) to create stable, high-relaxivity contrast agents for magnetic resonance imaging.
• Bifunctional Chelator Conjugation: The isothiocyanate (-NCS) group allows for covalent attachment to antibodies, peptides, or other targeting biomolecules.
• Molecular Imaging Probes: Used in the design and synthesis of probes for SPECT and PET imaging when complexed with appropriate radioisotopes.
• Research Chemical: Valuable tool in academic and industrial research for studying metal-ligand interactions, pharmacokinetics, and biodistribution.
• Theragnostic Agent Synthesis: Enables the creation of single molecules that combine diagnostic imaging and therapeutic capabilities.

Basic Information

Product Name	1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetraacetamide, 2-[(4-Isothiocyanatophenyl)Methyl]-
CAS No.	282097-63-6
Molecular Formula	C₂₈H₄₀N₁₀O₄S
Molecular Weight	612.76 g/mol
Synonyms	p-SCN-Bn-DOTA-tetraamide; 2-(4-Isothiocyanatobenzyl)-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid tetraamide; DOTA-tetraamide-NCS; Bifunctional DOTA-tetraamide; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetamide, 2-[(p-isothiocyanatophenyl)methyl]-; SCN-Bn-DOTA-tetraamide; 4-Isothiocyanatobenzyl-DOTA-tetraamide
EINECS	Contact for details

Quality Control

Our production of this high-value chelator adheres to strict quality protocols to ensure batch-to-batch consistency and purity suitable for pharmaceutical research and development. Each lot is characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your regulatory and R&D documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and degradation. For long-term stability, storage at -20°C is recommended.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.