Description

Carbamic Acid, [(1R,3S)-1-Ethyl-3-Hydroxybutyl]-, 1,1-Dimethylethyl Ester (9Ci) is a high-purity, stereochemically defined chiral intermediate of significant importance in advanced organic synthesis. This compound is valued for its role as a key building block in the development of complex, biologically active molecules, particularly within the pharmaceutical sector. It is primarily sought after by research institutions and manufacturers engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals where precise stereochemistry is critical for efficacy.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the research and development of new therapeutic agents, including potential enzyme inhibitors and receptor modulators.
• Asymmetric Synthesis: Used in stereoselective reactions to construct complex molecular architectures with high enantiomeric purity.
• Peptidomimetics Research: Serves as a protected amino acid derivative or a constrained scaffold in the design of peptide analogs and mimetics.
• Medicinal Chemistry: Employed in lead optimization and structure-activity relationship (SAR) studies to improve drug candidate properties.
• Fine Chemical Production: Utilized in the multi-step synthesis of specialty chemicals requiring specific stereochemical configurations.
• Process Chemistry Development: Acts as a reference standard or starting material for scaling up synthetic routes under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	Carbamic Acid, [(1R,3S)-1-Ethyl-3-Hydroxybutyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	280758-03-4
Molecular Formula	C12H25NO3
Molecular Weight	231.33 g/mol
Synonyms	tert-Butyl N-[(1R,3S)-1-ethyl-3-hydroxybutyl]carbamate; (1R,3S)-1-Ethyl-3-hydroxybutyl carbamic acid tert-butyl ester; N-Boc-(1R,3S)-1-ethyl-3-hydroxybutylamine; Boc-L-threoninol derivative; tert-Butyl ((1R,3S)-1-ethyl-3-hydroxybutyl)carbamate; (3S,5R)-5-Ethyl-3-hydroxytetrahydro-2H-pyran-2-one precursor; Chiral β-amino alcohol protected derivative.
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1R,3S)-1-Ethyl-3-Hydroxybutyl]-, 1,1-Dimethylethyl Ester (9Ci) adheres to stringent quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for research and development. Each lot is characterized using advanced analytical techniques including HPLC, GC, and chiral analysis. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles are provided and available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when appropriate to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.