Description

1-Trifluoromethylcyclobutane-1-Carboxylic Acid is a high-value, fluorinated building block characterized by its unique cyclobutane ring and trifluoromethyl group. This compound is essential for introducing lipophilicity and metabolic stability into target molecules, making it a critical intermediate in advanced synthetic chemistry. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders, oncology, and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the CF3 group enhances biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for specialty polymers and liquid crystals, contributing to materials with unique thermal and optical properties.
• Fluorine Chemistry: An important reagent for exploring new fluorination methodologies and constructing complex fluorinated molecular architectures in academic and industrial R&D.
• Peptidomimetics & Bioisosteres: The carboxylic acid functionality allows its incorporation as a non-natural amino acid analog or a bioisostere for tert-butyl or other bulky groups.

Basic Information

Product Name	1-Trifluoromethylcyclobutane-1-Carboxylic Acid
CAS No.	277756-45-3
Molecular Formula	C6H7F3O2
Molecular Weight	168.12 g/mol
Synonyms	Cyclobutane-1-carboxylic acid, 1-(trifluoromethyl)-; 1-(Trifluoromethyl)cyclobutane-1-carboxylic acid; 1-Trifluoromethyl-1-cyclobutanecarboxylic acid; α-Trifluoromethylcyclobutanecarboxylic acid; TFMC-CA; Trifluoromethylcyclobutane carboxylic acid
EINECS	Contact for details

Quality Control

Every batch of 1-Trifluoromethylcyclobutane-1-Carboxylic Acid is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment, ensuring full traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and organic solvents. The container must be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.