Description

8-Oxatricyclo[3.2.1.02,4]Octane,3,3-Difluoro-,(1R,2S,4R,5S)-Rel-(9Ci) is a high-purity, stereochemically defined fluorinated bicyclic ether building block of significant interest in advanced organic synthesis. Its unique, rigid molecular scaffold and fluorine substitution pattern make it a valuable intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry and material science.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in drug discovery programs targeting central nervous system (CNS) and metabolic diseases.
• Agrochemical Research: Used in the development of new generation herbicides, fungicides, and insecticides, where the fluorine atoms and rigid structure can enhance biological activity and environmental stability.
• Material Science Precursor: Acts as a monomer or cross-linking agent in the development of specialty polymers, resins, and advanced materials with specific thermal or chemical resistance properties.
• Ligand and Catalyst Development: Employed in the design and synthesis of novel chiral ligands and organocatalysts for asymmetric synthesis, leveraging its defined stereochemistry.
• Fluorine Chemistry Studies: A valuable substrate for investigating new fluorination methodologies and studying the stereoelectronic effects of fluorine in constrained ring systems.
• Chemical Biology Probes: Utilized to create molecular probes for studying enzyme mechanisms or protein-ligand interactions due to its ability to mimic transition states or natural substrates.

Basic Information

Product Name	8-Oxatricyclo[3.2.1.02,4]Octane,3,3-Difluoro-,(1R,2S,4R,5S)-Rel-(9Ci)
CAS No.	277755-62-1
Molecular Formula	C7H8F2O
Molecular Weight	146.14 g/mol
Synonyms	(1R,2S,4R,5S)-3,3-Difluoro-8-oxatricyclo[3.2.1.02,4]octane; rel-(1R,2S,4R,5S)-3,3-Difluoro-8-oxatricyclo[3.2.1.02,4]octane; 3,3-Difluoro-8-oxatricyclo[3.2.1.02,4]octane, (1R,2S,4R,5S)-rel-; Difluorinated Bicyclic Ether; 8-Oxatricyclo[3.2.1.02,4]octane, 3,3-difluoro-, (1R,2S,4R,5S)-rel-; 277755-62-1; Fluorinated Oxanorbornane Derivative
EINECS	Contact for details

Quality Control

Our 8-Oxatricyclo[3.2.1.02,4]Octane,3,3-Difluoro-,(1R,2S,4R,5S)-Rel-(9Ci) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC, NMR, and GC/MS, to ensure high chemical and enantiomeric purity suitable for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed under an inert atmosphere to prevent moisture absorption and degradation. Store away from incompatible materials such as strong bases and fluorides.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.