Description

(S)-1-[(R)-2-(Diphenylphosphino)Ferrocenyl]-Ethyldi-Tert.-Butylphosphine is a highly specialized, chiral ferrocenyl phosphine ligand, a cornerstone in modern asymmetric catalysis. Its value lies in its ability to induce exceptional enantioselectivity and catalytic activity in transition metal-catalyzed reactions, enabling the efficient synthesis of single-enantiomer compounds. This ligand is essential for R&D chemists and process engineers in the pharmaceutical, agrochemical, and fine chemical industries who require precise stereochemical control for developing new active ingredients and advanced materials.

Application

• As a privileged ligand for asymmetric hydrogenation of prochiral olefins, ketones, and imines.
• Critical component in asymmetric cross-coupling reactions (e.g., Suzuki-Miyaura, Buchwald-Hartwig) for C-C and C-N bond formation.
• Catalyst for enantioselective synthesis of pharmaceutical intermediates, including chiral amines and amino acid derivatives.
• Use in the production of agrochemicals requiring specific stereoisomers for enhanced activity and reduced environmental impact.
• Research and development of novel organometallic catalysts for academic and industrial discovery programs.
• Key reagent in the synthesis of advanced electronic materials and chiral polymers.

Basic Information

Product Name	(S)-1-[(R)-2-(Diphenylphosphino)Ferrocenyl]-Ethyldi-Tert.-Butylphosphine
CAS No.	277306-29-3
Molecular Formula	C32H38FeP2
Molecular Weight	540.44 g/mol
Synonyms	(S,R)-JOSIPHOS; (S)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethyldi-tert-butylphosphine; Josiphos SL-J009-1; (S)-1-[(R)-2-(Diphenylphosphino)ferrocenyl]ethylbis(1,1-dimethylethyl)phosphine; (1S)-1-[(1R)-2-(Diphenylphosphanyl)ferrocen-1-yl]ethyldi(tert-butyl)phosphane; Ferrocenyl Josiphos Ligand; SL-J009-1; JOSIPHOS-type ligand
EINECS	Contact for details

Quality Control

Every batch of our chiral phosphine ligands is produced and tested under strict quality protocols to ensure consistency and performance in sensitive catalytic applications. We provide comprehensive Certificates of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and identity confirmation. Our quality system is designed to meet the stringent requirements of GMP and ISO standards for advanced chemical synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C to prevent oxidation and degradation. This material is light-sensitive (store away from light) and easily oxidized (store under inert atmosphere). Keep the container sealed in a cool, dry, and well-ventilated place.

Specification

Item	Specification
Appearance	Orange to red crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.