Description

Ticagrelor Sulfone is a key pharmaceutical intermediate and metabolite of the antiplatelet drug Ticagrelor. This compound is critical for research and development in cardiovascular medicine, particularly for studying drug metabolism and developing analytical reference standards. It is primarily utilized by pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers of active pharmaceutical ingredients (APIs) for quality control and regulatory compliance purposes.

Application

• Pharmaceutical Reference Standard: Serves as a certified reference material (CRM) for the quantification and identification of Ticagrelor and its metabolites in drug substance and finished product analysis.
• Metabolite Research: Used in pharmacokinetic and pharmacodynamic studies to understand the metabolic pathway, efficacy, and safety profile of Ticagrelor.
• Analytical Method Development: Essential for developing and validating high-performance liquid chromatography (HPLC) and liquid chromatography-mass spectrometry (LC-MS/MS) methods in bioanalytical laboratories.
• Impurity Profiling: Employed as a specified impurity standard to monitor and control the quality of Ticagrelor API during manufacturing, ensuring compliance with ICH guidelines.
• Clinical Trial Support: Provides a critical benchmark for measuring metabolite levels in biological samples during clinical trials for new cardiovascular therapies.
• Synthetic Intermediate: Acts as a building block in the advanced synthesis of novel P2Y12 receptor antagonists and related chemical entities for drug discovery.

Basic Information

Item	Detail
Product Name	Ticagrelor Sulfone
CAS No.	274693-39-9
Molecular Formula	C23H28F2N6O4S
Molecular Weight	522.57 g/mol
Synonyms	AZD6140 Sulfone; (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-Difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol S-Oxide; Ticagrelor Metabolite AR-C124910XX; AR-C124910XX; Ticagrelor Sulfoxide (common misnomer)
EINECS	Contact for details

Quality Control

Our Ticagrelor Sulfone is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral purity determination, and identification by spectroscopic methods (IR, NMR, MS). We provide a detailed Certificate of Analysis (COA) with each shipment, which includes batch-specific results for identity, assay, purity, and related substances. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature, 15-25°C (59-77°F). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Related Substances (HPLC)	Individual unknown impurity: ≤ 0.5% Total impurities: ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.