Description

4-Chloro-3-(Trifluoromethyl)Phenylacetylene is a high-value, multi-functional aromatic alkyne building block. Its molecular structure, featuring both a chloro and a trifluoromethyl substituent on the phenyl ring, makes it a critical intermediate for synthesizing complex molecules with tailored electronic and steric properties. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and advanced materials sectors, where it is used to construct novel active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of novel herbicides, fungicides, and pesticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Material Science: Serves as a monomer or cross-linker in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Research: A versatile reagent for Sonogashira, Click, and other cross-coupling reactions to create complex conjugated systems for discovery chemistry.
• Ligand & Catalyst Development: Employed in the synthesis of sophisticated ligands for catalysis and molecular recognition applications.

Basic Information

Product Name	4-Chloro-3-(Trifluoromethyl)Phenylacetylene
CAS No.	273928-28-2
Molecular Formula	C9H4ClF3
Molecular Weight	204.58 g/mol
Synonyms	1-Chloro-4-ethynyl-2-(trifluoromethyl)benzene; 4-Chloro-α,α,α-trifluoro-3-ethynyltoluene; 3-Ethynyl-4-chlorobenzotrifluoride; 4-Chloro-3-(trifluoromethyl)ethynylbenzene; (4-Chloro-3-(trifluoromethyl)phenyl)acetylene; 4-Chloro-α,α,α-trifluoro-m-tolylacetylene
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized by modern analytical techniques including GC, HPLC, NMR, and IR spectroscopy to confirm identity and purity. Certificates of Analysis (COA) detailing all relevant specifications are available upon request, providing full traceability and quality assurance for your R&D and production needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. Due to its light-sensitive nature, containers should be kept in opaque or amber packaging.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.