Description

Fmoc-(Rs)-3-Amino-3-(4-Nitrophenyl)-Propionic Acid is a protected amino acid derivative featuring an Fmoc-protected amine group and a 4-nitrophenyl side chain. This compound is a critical chiral building block for the solid-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of unique structural motifs. It is primarily utilized by research institutions and pharmaceutical companies engaged in drug discovery, medicinal chemistry, and the development of novel bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key monomer for incorporating non-natural, aromatic amino acid residues into peptide chains.
• Pharmaceutical Research & Development: For creating targeted libraries of peptide-based drug candidates and investigating structure-activity relationships (SAR).
• Medicinal Chemistry: Serves as a versatile intermediate in the synthesis of peptidomimetics and constrained peptides with potential therapeutic applications.
• Bioconjugation: The reactive carboxylic acid group allows for coupling to other molecules, useful in probe and linker development.
• Chemical Biology: Used to synthesize peptide substrates or inhibitors for enzyme studies and biochemical assays.
• Material Science: Potential use in creating functionalized surfaces or polymers with peptide-based recognition elements.

Basic Information

Product Name	Fmoc-(Rs)-3-Amino-3-(4-Nitrophenyl)-Propionic Acid
CAS No.	273920-31-3
Molecular Formula	C24H20N2O6
Molecular Weight	432.43 g/mol
Synonyms	Fmoc-3-Amino-3-(4-nitrophenyl)propanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(4-nitrophenyl)propanoic acid; (RS)-3-[(9H-Fluoren-9-ylmethoxycarbonyl)amino]-3-(4-nitrophenyl)propionic acid; Fmoc-DL-3-Amino-3-(4-nitrophenyl)propionic acid; Fmoc-β3-hPhe(4-NO2)-OH; N-Fmoc-3-amino-3-(4-nitrophenyl)propanoic acid; 3-[(Fmoc-amino]-3-(4-nitrophenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(Rs)-3-Amino-3-(4-Nitrophenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for pharmaceutical research and peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	Racemic mixture (RS)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.