Description

3-Pyrrolidinamine, 1-(Trifluoroacetyl)-, (3R)- (9Ci) is a high-value, chiral pyrrolidine derivative characterized by a trifluoroacetyl-protected amine group. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, enabling the introduction of stereochemical complexity into target molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals where precise stereochemistry is paramount for biological activity.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel therapeutic agents, including central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the production of advanced, enantiomerically pure pesticides and herbicides to enhance efficacy and reduce environmental impact.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis.
• Peptidomimetics Research: Employed in the design and synthesis of peptidomimetic compounds for drug discovery programs.
• Chemical Biology Probes: Utilized to create labeled or modified probes for studying biological pathways and protein interactions.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects requiring high chiral purity.

Basic Information

Product Name	3-Pyrrolidinamine, 1-(Trifluoroacetyl)-, (3R)- (9Ci)
CAS No.	270584-80-0
Molecular Formula	C6H9F3N2O
Molecular Weight	182.15 g/mol
Synonyms	(3R)-1-(Trifluoroacetyl)-3-pyrrolidinamine; (R)-1-(Trifluoroacetyl)pyrrolidin-3-amine; (R)-3-Amino-1-(trifluoroacetyl)pyrrolidine; 1-(Trifluoroacetyl)-(3R)-3-pyrrolidinamine; (R)-N-(Trifluoroacetyl)-3-aminopyrrolidine; (3R)-1-(2,2,2-Trifluoroacetyl)-3-pyrrolidinamine; 270584-80-0; (R)-TFA-3-Aminopyrrolidine
EINECS	Contact for details

Quality Control

Our production of 3-Pyrrolidinamine, 1-(Trifluoroacetyl)-, (3R)- adheres to stringent quality management protocols to ensure batch-to-batch consistency and high chiral purity. Each lot is analyzed using advanced chromatographic (HPLC, GC) and spectroscopic (NMR, IR) techniques. A comprehensive Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and impurity profiles is provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.