Description

Cbz-4-Biphenyl-L-Ala CAS NO 270568-72-4 is a protected amino acid derivative where the L-alanine side chain is functionalized with a 4-biphenyl group and the amine is protected with a carboxybenzyl (Cbz) group. This compound is a crucial chiral building block in the synthesis of complex peptides and peptidomimetics, offering precise control over stereochemistry and molecular architecture. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of novel therapeutic agents, particularly in oncology and metabolic disease research.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the research and development of peptide-based drugs and bioactive molecules.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) to incorporate the biphenyl-alanine residue, which can enhance peptide stability and receptor binding affinity.
• Protease Inhibitor Development: Acts as a core component in designing inhibitors for enzymes like renin or HIV protease, where the biphenyl moiety mimics a transition state or fills a hydrophobic pocket.
• Chemical Biology Research: Employed in the study of protein-protein interactions and signal transduction pathways by creating tailored peptide probes.
• Material Science: Potential use in creating specialized polymers or surface coatings with specific chiral or aromatic properties.

Basic Information

Product Name	Cbz-4-Biphenyl-L-Ala
CAS No.	270568-72-4
Molecular Formula	C23H21NO4
Molecular Weight	375.42 g/mol
Synonyms	N-[(Benzyloxy)carbonyl]-4-biphenyl-L-alanine; N-Cbz-4-Biphenyl-L-alanine; (S)-2-(((Benzyloxy)carbonyl)amino)-3-([1,1'-biphenyl]-4-yl)propanoic acid; Z-4-Biphenyl-L-Ala-OH; Nα-Carbobenzoxy-4-biphenyl-L-alanine; Fmoc-4-Biphenyl-L-Ala precursor; Biphenylalanine derivative; CBZ-BIPHE-L-ALA
EINECS	Contact for details

Quality Control

Our Cbz-4-Biphenyl-L-Ala is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.