Description

Fmoc-(S)-3-Amino-4-(3-Methyl-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a 3-methylphenyl side chain. This compound is a critical chiral building block for the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, enabling the introduction of a hydrophobic, aromatic moiety. It is primarily utilized by pharmaceutical researchers, biotech companies, and CROs engaged in the development of novel therapeutic peptides, protease inhibitors, and targeted drug conjugates.

Application

• Peptide Drug Discovery: A key intermediate for incorporating a modified phenylalanine analog into peptide sequences to enhance binding affinity, metabolic stability, and lipophilicity.
• Solid-Phase Peptide Synthesis (SPPS): Directly used in Fmoc-chemistry SPPS protocols for the automated or manual construction of custom peptides and small proteins.
• Peptidomimetic Design: Serves as a scaffold for creating non-peptide compounds that mimic the structure and function of natural peptides, useful in oncology and metabolic disease research.
• Chemical Biology Probes: Employed in the synthesis of labeled or tagged peptides for studying protein-protein interactions, enzyme mechanisms, and cellular uptake.
• API Intermediate: Used in the research and development stages for potential Active Pharmaceutical Ingredients (APIs) targeting GPCRs and other protein targets.
• Library Synthesis: A valuable component for generating diverse combinatorial peptide libraries for high-throughput screening in drug discovery campaigns.

Basic Information

Product Name	Fmoc-(S)-3-Amino-4-(3-Methyl-Phenyl)-Butyric Acid
CAS No.	270062-94-7
Molecular Formula	C26H25NO4
Molecular Weight	415.48 g/mol
Synonyms	Fmoc-3-Amino-4-(3-methylphenyl)butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(3-methylphenyl)butanoic acid; (S)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(m-tolyl)butanoic acid; Fmoc-(S)-3-Amino-4-(m-tolyl)butyric acid; Fmoc-3-Amino-4-(3-methylphenyl)butyric acid; N-α-Fmoc-3-amino-4-(3-methylphenyl)butyric acid; Fmoc-3-Amino-4-(3-tolyl)butanoic acid
EINECS	Contact for details

Quality Control

Our Fmoc-(S)-3-Amino-4-(3-Methyl-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the exacting standards required for advanced peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment to guarantee traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the sealed container to equilibrate to room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.