Description

3-Butenoicacid,2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-3-Methyl-,(2S)-(9Ci) is a high-purity, non-natural amino acid derivative featuring a protected amine group and a terminal alkene handle, making it a versatile chiral building block for advanced synthesis. Its primary value lies in enabling the precise construction of complex peptide mimetics and other bioactive molecules with controlled stereochemistry. This compound is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel drug candidates, and in specialty chemical synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of novel active pharmaceutical ingredients (APIs), especially in peptide-based therapeutics.
• Peptidomimetic Synthesis: Used to incorporate non-standard amino acid residues into peptide chains, modifying stability, activity, and bioavailability.
• Chemical Biology Probes: Serves as a building block for creating labeled or tagged molecules used in proteomics and target identification studies.
• Ligand and Catalyst Development: Employed in the synthesis of chiral ligands for asymmetric catalysis or as a precursor for functionalized materials.
• Academic and R&D Laboratories: A valuable reagent for methodological development in organic and medicinal chemistry research.

Basic Information

Product Name	3-Butenoicacid,2-[[(1,1-Dimethylethoxy)Carbonyl]Amino]-3-Methyl-,(2S)-(9Ci)
CAS No.	269742-33-8
Molecular Formula	C11H19NO4
Molecular Weight	229.27 g/mol
Synonyms	(2S)-2-[(tert-Butoxycarbonyl)amino]-3-methylbut-3-enoic acid; Boc-D-2-amino-3-methyl-3-butenoic acid; (S)-2-((tert-Butoxycarbonyl)amino)-3-methyl-3-butenoic acid; Boc-Aib(Allyl)-OH; Boc-2-Amino-3-methyl-3-butenoic acid; N-Boc-3-methyl-D-2,3-dehydrovaline; N-(tert-Butoxycarbonyl)-3-methyl-D-2,3-dehydrovaline
EINECS	Contact for details

Quality Control

Our production of this advanced chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high chemical purity, critical for sensitive pharmaceutical R&D. Quality is verified through comprehensive analytical techniques including HPLC, chiral analysis, and NMR spectroscopy. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, enantiomeric excess, and other critical parameters.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.