Description

Fmoc-(R)-3-Amino-4-(4-Cyano-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative designed for advanced peptide synthesis and pharmaceutical research. This chiral building block is critical for introducing specific structural motifs into peptide chains, enabling the development of novel therapeutic agents and bioactive compounds. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on peptide-based drug discovery and development.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of complex peptides.
• Pharmaceutical Intermediates: Serves as a crucial chiral intermediate in the synthesis of peptide-based active pharmaceutical ingredients (APIs).
• Peptidomimetic Drug Design: Used to create peptide analogs with enhanced stability, bioavailability, and target specificity.
• Bioconjugation and Labeling: Facilitates the site-specific modification of peptides and proteins for diagnostic and therapeutic applications.
• Chemical Biology Research: A valuable tool for probing protein-protein interactions and enzyme mechanisms.
• Library Synthesis: For generating diverse combinatorial peptide libraries in high-throughput screening campaigns.

Basic Information

Product Name	Fmoc-(R)-3-Amino-4-(4-Cyano-Phenyl)-Butyric Acid
CAS No.	269726-87-6
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-(R)-3-Amino-4-(4-cyanophenyl)butanoic Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-cyanophenyl)propanoic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(4-cyanophenyl)-D-alanine; Fmoc-D-4-Cyanophenylalanine; Fmoc-D-Cpa-OH; Fmoc-D-4-CN-Phe-OH; Nα-Fmoc-4-cyano-D-phenylalanine
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-4-(4-Cyano-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral purity assessment, to ensure it meets the stringent requirements for peptide synthesis. Certificates of Analysis (COA) detailing identity, purity, and specific impurities are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions or inert atmosphere to maintain stability and purity. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.