Description

Fmoc-(R)-3-Amino-4-(2-Cyano-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a cyano-substituted phenyl side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the introduction of constrained, aromatic functionalities. It is primarily utilized by pharmaceutical R&D teams, CROs, and CDMOs engaged in the development of novel therapeutic peptides, protease inhibitors, and other bioactive molecules. The product is supplied with a guaranteed Certificate of Analysis to ensure batch-to-batch consistency for sensitive applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides with specific structural motifs.
• Pharmaceutical Research: Incorporation into peptide-based drug candidates targeting enzymes like proteases, where the cyano-phenyl group can act as a pharmacophore or binding element.
• Peptidomimetic Development: Serves as a scaffold for creating conformationally restricted peptide analogs with enhanced metabolic stability and receptor selectivity.
• Chemical Biology Probes: Used in the synthesis of labeled or modified peptides for studying protein-protein interactions and cellular pathways.
• API Intermediate Manufacturing: An essential raw material in the cGMP production of active pharmaceutical ingredients (APIs) for peptide therapeutics.
• Academic Research: For fundamental studies in organic chemistry, medicinal chemistry, and peptide science.

Basic Information

Product Name	Fmoc-(R)-3-Amino-4-(2-Cyano-Phenyl)-Butyric Acid
CAS No.	269726-81-0
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-D-3-Amino-4-(2-cyanophenyl)butyric acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(2-cyanophenyl)butanoic acid; Fmoc-3-Amino-4-(2-cyanophenyl)butyric acid, (R)-; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-4-(2-cyanophenyl)butanoic acid; Fmoc-(R)-Amino(2-cyanobenzyl)acetic acid derivative; Fmoc-D-A(2-CN-Phe)OH; Fmoc-(R)-3-Amino-4-(2-cyano-phenyl)-butanoic acid; N-α-Fmoc-(R)-3-amino-4-(2-cyanophenyl)butyric acid
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. Each batch is characterized by advanced analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, chiral purity, and chemical purity. Certificates of Analysis (COA) are available upon request, detailing all critical specifications. We adhere to a quality management system suitable for supplying materials for research and development under cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.