Description

Fmoc-(R)-3-Amino-4-(3-Trifluoromethyl-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring a chiral center and a trifluoromethylphenyl side chain. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the precise incorporation of fluorinated aromatic motifs into peptide sequences. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel peptide-based therapeutics, diagnostics, and bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid, it is a fundamental reagent for the automated synthesis of custom peptides.
• Pharmaceutical Intermediates: Serves as a key chiral intermediate in the research and development of new active pharmaceutical ingredients (APIs), particularly for metabolic diseases and oncology targets.
• Peptidomimetic Drug Design: The trifluoromethyl group enhances lipophilicity and metabolic stability, making this building block valuable for creating optimized peptide mimics.
• Chemical Biology Probes: Used to synthesize labeled or modified peptides for studying protein-protein interactions and enzyme mechanisms.
• Agrochemical Research: Applied in the discovery of novel peptide-based bioactive compounds for crop protection.

Basic Information

Product Name	Fmoc-(R)-3-Amino-4-(3-Trifluoromethyl-Phenyl)-Butyric Acid
CAS No.	269726-75-2
Molecular Formula	C26H22F3NO4
Molecular Weight	469.46 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-[3-(trifluoromethyl)phenyl]butanoic acid; Fmoc-(R)-3-Amino-4-(3-CF3-Ph)-Butyric Acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(3-(trifluoromethyl)phenyl)butanoic acid; Fmoc-3-Amino-4-(3-trifluoromethylphenyl)butyric acid; Fmoc-β3-homo-3-(trifluoromethyl)phenylalanine; Fmoc-(R)-β3-3-CF3-Ph-Ala-OH; N-α-Fmoc-(R)-3-amino-4-(3-trifluoromethylphenyl)butyric acid
EINECS	Contact for details

Quality Control

Every batch of Fmoc-(R)-3-Amino-4-(3-Trifluoromethyl-Phenyl)-Butyric Acid is manufactured under strict quality management systems. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for peptide synthesis and pharmaceutical R&D. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as chiral purity, chemical purity, and residual solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Allow the container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.