Description

2-(2-Fluorobiphenyl-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is a high-purity boronic ester derivative, a critical building block in modern synthetic organic chemistry. Its primary value lies in enabling efficient Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for constructing complex biaryl structures. This compound is essential for researchers and manufacturers in the pharmaceutical and advanced materials sectors, where it is used to develop active pharmaceutical ingredients (APIs) and organic electronic components.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly those containing fluorinated biphenyl motifs for enhanced metabolic stability and bioavailability.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boron reagent for palladium-catalyzed carbon-carbon bond formation to create complex biaryl and heterobiaryl systems.
• Agrochemical Research: Used in the development of new generation herbicides and fungicides that require specific fluorinated aromatic architectures.
• Organic Light-Emitting Diodes (OLEDs): Building block for synthesizing electron-transport or emissive layer materials in display and lighting technologies.
• Liquid Crystal & Polymer Synthesis: Intermediate for creating advanced monomers and functional materials with tailored electronic and optical properties.
• Chemical Biology & Probe Development: Utilized in the creation of molecular probes and tags for imaging and diagnostic applications.

Basic Information

Product Name	2-(2-Fluorobiphenyl-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane
CAS No.	269410-15-3
Molecular Formula	C24H24BFO2
Molecular Weight	374.26 g/mol
Synonyms	2-(2'-Fluoro[1,1'-biphenyl]-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 2-(2-Fluorobiphenyl-4-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane; 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2'-fluorobiphenyl; 2'-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl; 2-Fluoro-4'-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)biphenyl; (2'-Fluoro[1,1'-biphenyl]-4-yl)boronic acid pinacol ester; 2-Fluorobiphenyl-4-boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-(2-Fluorobiphenyl-4-Yl)-4,4,5,5-Tetramethyl-1,3,2-Dioxaborolane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to support your R&D and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.