Description

Boc-(R)-3-Amino-4-(3-Methyl-Phenyl)-Butyric Acid is a high-purity, chiral non-natural amino acid derivative protected with a tert-butoxycarbonyl (Boc) group. This compound serves as a critical building block in the synthesis of complex peptides and peptidomimetics, offering precise stereochemical control. It is primarily utilized by research institutions and pharmaceutical companies engaged in the development of therapeutic agents, including enzyme inhibitors and receptor modulators.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to introduce a constrained, hydrophobic amino acid residue.
• Protease Inhibitor Development: Serves as a core structural component in the design of inhibitors for various proteolytic enzymes.
• Chemical Biology Research: Employed in the study of protein-protein interactions and the creation of custom peptide libraries for screening.
• Bioconjugation: The carboxylic acid and protected amine functionalities allow for selective conjugation to other molecules or surfaces.

Basic Information

Product Name	Boc-(R)-3-Amino-4-(3-Methyl-Phenyl)-Butyric Acid
CAS No.	269398-83-6
Molecular Formula	C16H23NO4
Molecular Weight	293.36 g/mol
Synonyms	(R)-3-((tert-Butoxycarbonyl)amino)-4-(3-methylphenyl)butanoic acid; Boc-D-3-Amino-4-(3-methylphenyl)butyric acid; (R)-Boc-3-Amino-4-(m-tolyl)butyric acid; N-Boc-3-Amino-4-(3-methylphenyl)-(R)-butanoic Acid; N-(tert-Butoxycarbonyl)-3-amino-4-(3-methylphenyl)-(R)-butyric acid; BOC-(R)-3-AMINO-4-(3-METHYL-PHENYL)-BUTYRIC ACID; (R)-N-Boc-3-amino-4-(m-tolyl)butanoic acid
EINECS	Contact for details

Quality Control

Our Boc-(R)-3-Amino-4-(3-Methyl-Phenyl)-Butyric Acid is manufactured under controlled conditions to ensure batch-to-batch consistency and high chemical purity. Each lot undergoes rigorous analytical testing, including chiral HPLC to confirm enantiomeric excess. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% e.e.
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.