Description

Fmoc-(R)-3-Amino-4-(2,4-Dichloro-Phenyl)-Butyric Acid is a high-purity, non-natural amino acid derivative featuring an Fmoc-protected amine group and a dichlorophenyl side chain. This compound is a critical chiral building block for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, enabling the introduction of unique hydrophobic and sterically demanding motifs. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel therapeutic peptides, protease inhibitors, and constrained analogs with enhanced metabolic stability.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel peptide-based drugs and bioactive compounds.
• Solid-Phase Peptide Synthesis (SPPS): Used as an Fmoc-protected amino acid for the automated or manual synthesis of custom peptides with specific structural features.
• Peptidomimetic Design: Incorporates the 2,4-dichlorophenyl group to mimic protein side chains, aiding in the creation of molecules with improved binding affinity and pharmacokinetic properties.
• Protease Inhibitor Development: Serves as a core component for designing inhibitors targeting specific proteolytic enzymes.
• Chemical Biology Research: Utilized in the study of protein-protein interactions and the structure-activity relationships (SAR) of peptides.
• API (Active Pharmaceutical Ingredient) Synthesis: Employed in the multi-step synthesis of complex active pharmaceutical ingredients requiring this specific chiral amino acid framework.

Basic Information

Product Name	Fmoc-(R)-3-Amino-4-(2,4-Dichloro-Phenyl)-Butyric Acid
CAS No.	269396-54-5
Molecular Formula	C25H21Cl2NO4
Molecular Weight	470.34 g/mol
Synonyms	N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-4-(2,4-dichlorophenyl)butanoic acid; Fmoc-D-2,4-Dichlorophenylalanine(3-Homo); Fmoc-(R)-3-Amino-4-(2,4-dichlorophenyl)butanoic acid; (R)-2-(((9H-Fluoren-9-yl)methoxy)carbonylamino)-4-(2,4-dichlorophenyl)butanoic acid; Fmoc-3-Amino-4-(2,4-dichloro-phenyl)-butyric acid; Fmoc-(R)-3-Ahdc-OH; Fmoc-D-3-Amino-4-(2,4-dichlorophenyl)butyric acid
EINECS	Contact for details

Quality Control

Our Fmoc-(R)-3-Amino-4-(2,4-Dichloro-Phenyl)-Butyric Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric purity and standard pharmacopeial identification tests, to ensure it meets the high-purity standards required for pharmaceutical research and development. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccant and inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.