Description

Carbamic Acid, [(1S)-1-Methyl-2,3-Dioxopropyl]-, 1,1-Dimethylethyl Ester (9Ci) is a specialized chiral building block and protected amino acid derivative of significant interest in advanced organic synthesis. Its core value lies in providing a stereochemically defined scaffold for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), peptides, and other bioactive compounds where precise stereochemistry is critical.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of potential drug candidates, especially for central nervous system (CNS) and metabolic disease targets.
• Peptidomimetics & Constrained Peptide Synthesis: Used to introduce non-natural amino acid residues and conformational constraints into peptide backbones to enhance stability and bioavailability.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric reactions to create enantiomerically pure compounds.
• Protecting Group Strategy: The tert-butyloxycarbonyl (Boc) and dioxopropyl groups offer orthogonal protection for amines and carbonyls in complex synthetic sequences.
• Chemical Biology Probes: Utilized in the development of activity-based probes and labeled compounds for studying enzyme mechanisms and biological pathways.
• Agrochemical Research: Potential intermediate in the synthesis of chiral, bioactive compounds for crop protection and agrochemical development.

Basic Information

Product Name	Carbamic Acid, [(1S)-1-Methyl-2,3-Dioxopropyl]-, 1,1-Dimethylethyl Ester (9Ci)
CAS No.	269079-88-1
Molecular Formula	C10H17NO5
Molecular Weight	231.25 g/mol
Synonyms	(3S)-3-[(tert-Butoxycarbonyl)amino]-2-oxobutanal; (S)-3-((tert-Butoxycarbonyl)amino)-2-oxobutanal; Boc-L-3-Amino-2-oxobutanal; tert-Butyl (1S)-1-methyl-2,3-dioxopropylcarbamate; (S)-3-(Boc-amino)-2-oxobutyraldehyde; N-Boc-3-amino-2-oxobutanal (S-enantiomer); (S)-Boc-Aminodioxobutane
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1S)-1-Methyl-2,3-Dioxopropyl]-, 1,1-Dimethylethyl Ester (9Ci) adheres to stringent quality systems suitable for research and cGMP-grade applications. Each batch is characterized by advanced analytical techniques including HPLC, chiral HPLC, NMR, and MS to ensure identity, purity, and enantiomeric excess. Certificates of Analysis (COA) with full analytical data are provided, and we support customer audits and regulatory documentation requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) under an inert atmosphere (e.g., nitrogen or argon) for long-term stability. This compound is moisture-sensitive and should be handled in a dry environment. Allow the sealed container to reach ambient temperature before opening to prevent condensation.

Specification

Item	Specification
Appearance	White to off-white solid or oil
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Enantiomeric Excess (Chiral HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.