Description

(R,S)-Fmoc-3-Amino-3-(Biphenyl)-Propionic Acid CAS NO 269078-79-7 is a high-purity, non-natural amino acid derivative protected with a 9-fluorenylmethoxycarbonyl (Fmoc) group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled introduction of a biphenyl side chain to modulate peptide properties. It is essential for researchers and manufacturers in pharmaceutical development, particularly for creating novel peptide-based therapeutics, diagnostics, and chemical biology probes. The racemic (R,S) mixture provides versatility for various research and screening applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Research: Used to incorporate hydrophobic biphenyl motifs into peptide drug candidates to enhance binding affinity or alter pharmacokinetic properties.
• Chemical Biology: Serves as a building block for synthesizing peptide libraries used in high-throughput screening and structure-activity relationship (SAR) studies.
• Peptidomimetic Development: Facilitates the creation of peptide analogs and mimetics with improved stability and bioactivity.
• Bioconjugation: The carboxylic acid and amine functionalities allow for further derivatization and conjugation to other molecules or surfaces.
• Academic & Industrial R&D: A fundamental reagent for exploring new peptide sequences and their functions in both academic and commercial research settings.

Basic Information

Item	Detail
Product Name	(R,S)-Fmoc-3-Amino-3-(Biphenyl)-Propionic Acid
CAS No.	269078-79-7
Molecular Formula	C30H25NO4
Molecular Weight	463.52 g/mol
Synonyms	Fmoc-3-Amino-3-(1,1'-biphenyl-4-yl)propanoic Acid; Fmoc-DL-3-Amino-3-(4-biphenylyl)propionic Acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-amino-3-(biphenyl-4-yl)propanoic Acid; (R,S)-Fmoc-Amino-biphenyl-propionic Acid; Fmoc-3-Amino-3-(4-phenylphenyl)propanoic Acid; DL-Fmoc-3-Amino-3-(biphenyl-4-yl)propionic Acid; N-Fmoc-3-amino-3-(4-biphenylyl)propanoic acid; 3-[(9-Fluorenylmethoxycarbonyl)amino]-3-(4-biphenylyl)propanoic acid
EINECS	Contact for details

Quality Control

Our (R,S)-Fmoc-3-Amino-3-(Biphenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements for peptide synthesis. Certificates of Analysis (COA) providing detailed results for purity, identity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.