Description

Fmoc-D-Hocha-Oh CAS NO 269078-72-0 is a high-purity, non-natural amino acid derivative specifically engineered for advanced peptide synthesis and pharmaceutical research. This compound is a critical building block for the solid-phase synthesis of complex peptides, enabling the precise incorporation of the D-configuration of the HoCha (homochorismic acid derivative) moiety. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on developing novel therapeutic peptides, peptidomimetics, and biochemical probes. The product is supplied under stringent quality control to ensure batch-to-batch consistency and optimal performance in sensitive synthetic applications.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid for the automated synthesis of custom peptides.
• Pharmaceutical Intermediate: For the research and development of peptide-based active pharmaceutical ingredients (APIs) and drug candidates.
• Bioconjugation & Probe Development: Used to introduce specific functional handles into peptides for labeling, imaging, or targeting applications.
• Peptidomimetic Design: Serves as a scaffold for creating modified peptides with enhanced stability, bioavailability, or receptor affinity.
• Biochemical Research: Employed in academic and industrial labs to study enzyme-substrate interactions, protein folding, and molecular recognition.
• Combinatorial Chemistry Libraries: A valuable component for generating diverse libraries of compounds for high-throughput screening.

Basic Information

Product Name	Fmoc-D-Hocha-Oh
CAS No.	269078-72-0
Molecular Formula	C₂₅H₂₇NO₆
Molecular Weight	437.49 g/mol
Synonyms	Fmoc-D-homochorismate; (2R)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-[(1-carboxyethenyl)oxy]butanoic acid; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-homochorismic acid; Fmoc-D-HoCha-OH; Fmoc-D-2-amino-4-((1-carboxyvinyl)oxy)butanoic acid; Nα-Fmoc-D-homochorismic acid
EINECS	Contact for details

Quality Control

Our Fmoc-D-Hocha-Oh is manufactured under controlled conditions to meet the exacting standards required for pharmaceutical research and peptide synthesis. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and comprehensive identification tests. A Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to ensure full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.