Description

[Nphe1]Nociceptin(1-13)NH2 is a potent and selective peptide antagonist of the nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP receptor). This compound is a critical research tool for investigating the N/OFQ-NOP receptor system, which plays a significant role in modulating pain, anxiety, and reward pathways. It is primarily utilized by pharmaceutical researchers, neuroscientists, and academic institutions engaged in neuropharmacology, pain management research, and central nervous system drug discovery.

Application

• Neuroscience Research: A key pharmacological tool for studying the function of the nociceptin/orphanin FQ (N/OFQ) system in the brain and spinal cord.
• Pain Mechanism Studies: Used to antagonize NOP receptor activity to elucidate its role in nociception, analgesia, and hyperalgesia.
• Behavioral Pharmacology: Employed in animal models to investigate the effects of NOP receptor blockade on anxiety, depression, stress, and reward-related behaviors.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel NOP receptor-targeted therapeutics for pain, addiction, and mood disorders.
• Receptor Binding Assays: Used in competitive binding experiments to characterize receptor affinity and selectivity for new chemical entities.
• Signal Transduction Research: Applied in cellular assays to study NOP receptor-mediated inhibition of cAMP accumulation and other downstream signaling events.

Basic Information

Product Name	[Nphe1]Nociceptin(1-13)NH2
CAS No.	267234-08-2
Molecular Formula	C78H108N20O17
Molecular Weight	1597.8 g/mol
Synonyms	[Nphe1]Nociceptin(1-13)amide; [Nphe1]NC(1-13)NH2; Nociceptin (1-13) amide, [Nphe1]-; [Phe1ψ(CH2-NH)Gly2]Nociceptin(1-13)NH2; NOP receptor antagonist; Orphanin FQ receptor antagonist; (Nphe(1))N/OFQ(1-13)-NH2
EINECS	Contact for details

Quality Control

Our peptide products are synthesized and purified under stringent conditions to ensure the highest standards of identity, purity, and biological activity. Each batch is subjected to comprehensive analytical characterization, including HPLC for purity assessment and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing all analytical results are provided and available upon request to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.