Description

3,5-Difluoro-D-Phenylalanine is a non-natural, fluorinated derivative of the essential amino acid D-phenylalanine, distinguished by fluorine atoms at the 3 and 5 positions of the aromatic ring. This structural modification is critical for enhancing metabolic stability, altering lipophilicity, and serving as a key synthetic building block in advanced pharmaceutical research and development. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications ranging from peptide-based drug discovery to the synthesis of novel bioactive compounds.

Application

• Pharmaceutical Intermediate: A crucial chiral building block for the synthesis of novel peptide-based therapeutics and protease inhibitors.
• PET (Positron Emission Tomography) Tracer Precursor: Used in the development of fluorine-18 (18F) labeled radiopharmaceuticals for diagnostic imaging.
• Agrochemical Research: Serves as a key intermediate in the design and synthesis of new-generation herbicides and pesticides with improved properties.
• Peptide Modification & Conjugation: Enables the site-specific incorporation of fluorine atoms into peptides to study structure-activity relationships (SAR) and enhance bioavailability.
• Biochemical Tool Compound: Used in enzymatic studies and as a substrate analog to investigate amino acid metabolism and transport mechanisms.
• Material Science: Employed in the synthesis of specialized fluorinated polymers and advanced organic materials.

Basic Information

Product Name	3,5-Difluoro-D-Phenylalanine
CAS No.	266360-63-8
Molecular Formula	C9H9F2NO2
Molecular Weight	201.17 g/mol
Synonyms	D-3,5-Difluorophenylalanine; (R)-2-Amino-3-(3,5-difluorophenyl)propanoic acid; (R)-3,5-Difluorophenylalanine; 3,5-Difluoro-D-Phe; 3,5-Difluoro-D-Phe-OH; 3,5-DiF-D-Phenylalanine; D-3,5-DiF-Phe
EINECS	Contact for details

Quality Control

Our 3,5-Difluoro-D-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with high-purity standards suitable for research and development. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (D-Isomer)
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.