Description

Fmoc-Dl-4-Cyanophenylalanine is a protected, non-natural amino acid derivative essential for advanced peptide synthesis. This compound is a critical building block for introducing the unique 4-cyanophenylalanine side chain, which is valuable for studying protein structure, function, and interactions through biophysical techniques. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies engaged in peptide-based drug discovery and chemical biology.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key monomer for the controlled incorporation of the 4-cyanophenylalanine residue into peptide chains, enabling the study of protein folding and stability.
• Biophysical Probe Development: The cyano group serves as a sensitive infrared (IR) reporter and vibrational probe for analyzing local protein environments and conformational changes.
• Peptidomimetic & Drug Discovery: Used in the design and synthesis of novel peptide therapeutics, enzyme inhibitors, and receptor ligands where the aromatic nitrile functionality modulates bioactivity and binding affinity.
• Chemical Biology Research: Facilitates site-specific labeling and post-translational modification studies in synthetic peptides and proteins.
• Material Science: Employed in the synthesis of specialized polymers and biomaterials that require amino acid-based building blocks with unique electronic properties.

Basic Information

Product Name	Fmoc-Dl-4-Cyanophenylalanine
CAS No.	265321-37-7
Molecular Formula	C26H22N2O4
Molecular Weight	426.47 g/mol
Synonyms	Fmoc-4-CN-Phe-OH; Fmoc-p-Cyanophenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-cyano-DL-phenylalanine; N-Fmoc-4-cyano-DL-phenylalanine; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-cyanophenyl)propanoic acid; Fmoc-DL-Phe(4-CN)-OH; DL-4-Cyanophenylalanine, N-Fmoc derivative
EINECS	Contact for details

Quality Control

Our Fmoc-Dl-4-Cyanophenylalanine is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity assessment and spectroscopic methods for structural confirmation, to ensure it meets the high standards required for research and development. Certificates of Analysis (COA) with detailed specifications are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.