Description

Fmoc-L-Phe(4-Nhac) CAS NO 265321-34-4 is a protected amino acid derivative, specifically an N-Fmoc-protected L-phenylalanine analog with an acetamido group at the para position. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled assembly of complex peptides and proteins. It is primarily utilized by research institutions, pharmaceutical developers, and biotechnology companies engaged in peptide-based drug discovery, therapeutic agent development, and biochemical research.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental building block for the automated, sequential assembly of custom peptides.
• Pharmaceutical Research & Development: Used in the synthesis of peptide drug candidates, including potential therapeutics for metabolic disorders, oncology, and infectious diseases.
• Bioconjugation and Protein Engineering: Serves as a modified amino acid precursor for introducing specific functional handles or labels into synthetic peptides.
• Combinatorial Chemistry Libraries: A key component in generating diverse peptide libraries for high-throughput screening against biological targets.
• Academic and Industrial Research: Employed in studies of protein-protein interactions, enzyme substrates, and receptor ligands.
• Production of Biologically Active Peptides: Facilitates the synthesis of peptides with potential hormonal, antimicrobial, or signaling activities.

Basic Information

Product Name	Fmoc-L-Phe(4-Nhac)
CAS No.	265321-34-4
Molecular Formula	C26H24N2O5
Molecular Weight	444.48 g/mol
Synonyms	Fmoc-4-acetamido-L-phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-4-acetamido-L-phenylalanine; Fmoc-Phe(4-NHAc)-OH; Fmoc-L-4-Acetamidophenylalanine; Nα-Fmoc-N4-acetyl-L-phenylalanine; (2S)-2-[(9H-Fluoren-9-ylmethoxy)formamido]-3-[4-(acetylamino)phenyl]propanoic acid; Fmoc-Phe(Ac4NH)-OH; Fmoc-L-Phe(p-NHAc)-OH
EINECS	Contact for details

Quality Control

Our Fmoc-L-Phe(4-Nhac) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing purity, assay, and impurity profiles are available upon request, supporting compliance with research and cGMP guidelines where applicable.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a desiccated environment to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Optical Rotation	-15.0° to -25.0° (c=1 in DMF)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.