Description

n-Fmoc-Dl-3-(1,1-Dimethylethoxy)-Phenylalanine is a protected amino acid derivative, specifically engineered for advanced peptide synthesis. This compound is a critical building block in solid-phase peptide synthesis (SPPS), where the Fmoc group provides orthogonal protection for the α-amino group. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel peptide-based therapeutics, diagnostics, and research tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the controlled, sequential assembly of complex peptides using Fmoc chemistry.
• Pharmaceutical Research: Used in the discovery and development of peptide drugs, including hormone analogs, enzyme inhibitors, and receptor agonists/antagonists.
• Combinatorial Chemistry Libraries: Serves as a versatile monomer for generating diverse peptide libraries for high-throughput screening.
• Bioconjugation: Facilitates the site-specific incorporation of modified phenylalanine residues into peptides for labeling or functionalization.
• Academic & Contract Research: Supports fundamental research in biochemistry, medicinal chemistry, and chemical biology.
• Production of Protected Peptide Fragments: Enables the synthesis of specific, protected peptide segments for fragment condensation strategies.

Basic Information

Product Name	n-Fmoc-Dl-3-(1,1-Dimethylethoxy)-Phenylalanine
CAS No.	265321-17-3
Molecular Formula	C28H29NO5
Molecular Weight	459.54 g/mol
Synonyms	Fmoc-DL-3-(tert-Butoxy)phenylalanine; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-3-(tert-butoxy)-DL-phenylalanine; N-Fmoc-3-(tert-butoxy)-DL-phenylalanine; DL-3-(tert-Butoxy)phenylalanine, N-Fmoc derivative; Fmoc-3-(O-tert-butyl)-DL-Phe-OH; (RS)-2-(((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(3-(tert-butoxy)phenyl)propanoic acid
EINECS	Contact for details

Quality Control

Our n-Fmoc-Dl-3-(1,1-Dimethylethoxy)-Phenylalanine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for sensitive peptide synthesis applications. Certificates of Analysis (COA) detailing purity, chiral composition, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (DL Ratio)	~50:50 (Racemic mixture)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.