Description

Caspase-9 CAS NO 265294-58-4 is a critical cysteine-aspartic acid protease enzyme that plays a central role in the intrinsic apoptosis pathway, a fundamental process for programmed cell death. Its precise activity is essential for cellular homeostasis, development, and the elimination of damaged or potentially dangerous cells. This makes it a vital research tool and a key target for therapeutic development in oncology, neurology, and immunology, serving pharmaceutical R&D, academic research, and diagnostic development sectors.

Application

• Biochemical Research: Used as a key reagent to study the mechanisms of apoptosis (programmed cell death) and caspase activation cascades in cellular models.
• Drug Discovery & Screening: Employed in high-throughput assays to identify and validate novel pro-apoptotic compounds or caspase-9 inhibitors for cancer and neurodegenerative disease research.
• Diagnostic Development: Serves as a component in developing assays to measure caspase-9 activity as a biomarker for apoptosis in clinical and preclinical samples.
• Enzymology Studies: Utilized to investigate enzyme kinetics, substrate specificity, and the effects of regulatory proteins on caspase-9 function.
• Cell Biology: Applied in experiments to induce or inhibit apoptosis in cell cultures to understand disease pathology and test therapeutic interventions.
• Recombinant Protein Production: Used as a standard or control in the production and quality control of recombinant caspase-9 proteins.

Basic Information

Product Name	Caspase-9
CAS No.	265294-58-4
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	Caspase 9; Apoptotic protease Mch-6; APAF-3; ICE-like apoptotic protease 6; ICE-LAP6; Caspase-9 subunit p10; Caspase-9 subunit p35; CASP9; MCH6
EINECS	Contact for details

Quality Control

Our Caspase-9 is produced and tested under stringent conditions to ensure high purity, consistent activity, and batch-to-batch reproducibility suitable for sensitive research applications. Quality is verified through a comprehensive panel of analytical methods, including activity assays, purity assessment, and identity confirmation. A detailed Certificate of Analysis (COA) is provided with each batch, documenting all relevant specifications and test results.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake. For optimal performance, prepare working aliquots to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (IR)	Conforms
Purity (SDS-PAGE)	≥ 90%
Specific Activity	≥ [Value] units/mg protein
Endotoxin Level	< 1.0 EU/μg
Solubility	Soluble in appropriate assay buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.