Description

Quercetin-D3 (Major) is a high-purity, deuterium-labeled isotopologue of the natural flavonoid quercetin, serving as a critical internal standard for analytical quantification. This compound is essential for ensuring accuracy and reliability in mass spectrometry-based research, eliminating variability and enabling precise metabolic and pharmacokinetic studies. It is primarily required by analytical laboratories, pharmaceutical R&D departments, and nutraceutical manufacturers engaged in advanced bioanalysis and quality control.

Application

• Internal Standard for LC-MS/MS: Used as a quantitative reference standard in liquid chromatography-tandem mass spectrometry for the accurate measurement of quercetin and its metabolites in complex biological matrices.
• Pharmacokinetic & Bioavailability Studies: Enables precise tracking of absorption, distribution, metabolism, and excretion (ADME) of quercetin in preclinical and clinical research.
• Nutraceutical & Dietary Supplement Analysis: Critical for the quality control and assay verification of quercetin content in finished products like capsules, tablets, and extracts.
• Metabolomics Research: Facilitates the identification and quantification of quercetin-derived metabolites in metabolic pathway studies.
• Method Development & Validation: Serves as a key component in developing and validating robust analytical methods for flavonoid analysis in compliance with ICH and FDA guidelines.
• Food & Beverage Fortification Analysis: Used to assay quercetin levels in fortified foods and functional beverages to ensure label claim accuracy.

Basic Information

Product Name	Quercetin-D3 (Major)
CAS No.	263711-79-1
Molecular Formula	C15H7D3O7
Molecular Weight	305.25 g/mol
Synonyms	2-(3,4-Dihydroxyphenyl)-3,5,7-trihydroxy-4H-chromen-4-one-d3; 3,3',4',5,7-Pentahydroxyflavone-d3; Quercetin (phenyl-d3); Quercetin-d3 (Major Isotopologue); [2H3]-Quercetin; Deuterated Quercetin; Quercetin Internal Standard; Meletin-d3
EINECS	Contact for details

Quality Control

Every batch of Quercetin-D3 (Major) is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure exceptional isotopic purity and chemical identity. Our quality assurance protocol includes comprehensive characterization by NMR, HPLC, and mass spectrometry to confirm deuterium incorporation and absence of unlabeled quercetin. A detailed Certificate of Analysis (COA) providing batch-specific data for purity, isotopic enrichment, and solvent residues is supplied with each shipment to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to minimize oxidation. Keep the container in a cool, dry, and well-ventilated area separate from strong oxidizing agents.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D3)	≥ 98.0 atom % D
Chemical Purity	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.