Description

1-Bromo-2-(Difluorophenylmethyl)Benzene is a high-purity, specialized aromatic bromide building block. This compound is valued for its unique difluorinated benzyl moiety, which is critical for modulating the physicochemical and metabolic properties of advanced chemical entities. It is primarily sought by R&D and process chemistry teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and development of new herbicides and fungicides, where the difluoromethyl group can enhance bioavailability and stability.
• Material Science Research: Serves as a precursor for advanced organic electronic materials, including ligands for OLEDs and charge-transport molecules.
• Ligand & Catalyst Development: Employed in the preparation of specialized ligands for transition metal catalysis in cross-coupling reactions.
• Fluorine Chemistry Studies: A valuable substrate for investigating structure-activity relationships (SAR) in medicinal and agrochemical chemistry due to its specific fluorine substitution pattern.

Basic Information

Product Name	1-Bromo-2-(Difluorophenylmethyl)Benzene
CAS No.	263249-01-0
Molecular Formula	C₁₃H₉BrF₂
Molecular Weight	283.11 g/mol
Synonyms	2-(Bromomethyl)-1,1'-biphenyl, 3',5'-Difluoro Derivative; 1-Bromo-2-[(3,5-difluorophenyl)methyl]benzene; [1,1'-Biphenyl]-2-ylmethyl bromide, 3',5'-difluoro-; α-Bromo-3,5-difluorobiphenyl-2-ylmethane; 2-(Bromomethyl)-3',5'-difluorobiphenyl; (3,5-Difluorobiphenyl-2-yl)methyl bromide
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-2-(Difluorophenylmethyl)Benzene is manufactured under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high standards required for research and scale-up applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is supplied with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.