Description

L-Lysine, N2,N6-Bis[(1,1-Dimethylethoxy)Carbonyl]-N6-Methyl- is a protected derivative of the essential amino acid L-lysine, featuring Boc (tert-butoxycarbonyl) protecting groups on both the N2 and N6 amines, with an additional methyl group on the N6 position. This specific chemical modification is crucial for advanced peptide synthesis, providing enhanced stability and controlled reactivity during complex coupling sequences. It is primarily utilized by pharmaceutical R&D laboratories and fine chemical manufacturers specializing in the production of therapeutic peptides, peptidomimetics, and other bioactive compounds.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key building block for the controlled incorporation of methylated lysine residues into peptide chains, essential for studying post-translational modifications.
• Pharmaceutical Research: Used in the development of novel peptide-based drugs targeting various diseases, where specific lysine modifications can alter bioactivity and stability.
• Bioconjugation & Chemical Biology: Serves as a precursor for creating specialized linkers and probes to study protein-protein interactions and enzyme function.
• Production of Custom Peptides: Enables contract research and manufacturing organizations (CROs/CMOs) to synthesize high-purity, sequence-specific peptides for clients.
• Academic Research: A critical reagent in university and institutional labs for fundamental research in biochemistry, molecular biology, and medicinal chemistry.

Basic Information

Product Name	L-Lysine, N2,N6-Bis[(1,1-Dimethylethoxy)Carbonyl]-N6-Methyl-
CAS No.	263247-78-5
Molecular Formula	C18H34N2O6
Molecular Weight	374.48 g/mol
Synonyms	Nε-Methyl-Nα,Nε-bis-Boc-L-lysine; N6-Methyl-N2,N6-bis(tert-butoxycarbonyl)-L-lysine; Boc-Lys(Me,Boc)-OH; (2S)-6-[(tert-Butoxycarbonyl)(methyl)amino]-2-[(tert-butoxycarbonyl)amino]hexanoic acid; Nα,Nε-Di-Boc-Nε-methyl-L-lysine; MeBoc-Lys(Boc)-OH; Fmoc-Lys(Me,Boc)-OH precursor; Protected N6-methyl-L-lysine derivative
EINECS	Contact for details

Quality Control

Our L-Lysine, N2,N6-Bis[(1,1-Dimethylethoxy)Carbonyl]-N6-Methyl- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and synthesis applications. Each lot is analyzed using advanced techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and the absence of critical impurities. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C for long-term stability. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. Allow the sealed container to equilibrate to room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Optical Rotation	[α]D20: Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.