Description

Carbamic Acid, [(1S)-1-(Hydroxymethyl)-1-Methyl-2-Propynyl]-, 1,1- is a specialized chiral building block featuring a carbamate-protected propargylic alcohol moiety. This compound is valued for its role in advanced organic synthesis, particularly in the construction of complex molecules where stereochemistry and functional group compatibility are critical. It serves as a key intermediate for researchers and manufacturers in the pharmaceutical and agrochemical industries, enabling the development of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of active pharmaceutical ingredients (APIs), especially in the development of central nervous system (CNS) drugs and enzyme inhibitors.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, leveraging its propargyl group for click chemistry and other coupling reactions.
• Peptide Mimetics & PROTACs: Serves as a building block for creating peptide analogs and Proteolysis Targeting Chimeras (PROTACs) due to its carbamate protecting group and alkyne functionality.
• Material Science Research: Employed in the development of novel polymers and dendrimers, where its reactive alkyne group allows for controlled polymerization or cross-linking.
• Asymmetric Catalysis Ligand Precursor: Acts as a precursor for chiral ligands used in asymmetric hydrogenation and other enantioselective transformations.
• Bioconjugation Chemistry: The alkyne handle facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAC) for labeling biomolecules in diagnostic and biotech applications.

Basic Information

Product Name	Carbamic Acid, [(1S)-1-(Hydroxymethyl)-1-Methyl-2-Propynyl]-, 1,1-
CAS No.	263017-03-4
Molecular Formula	C7H11NO3
Molecular Weight	157.17 g/mol
Synonyms	(1S)-1-(Hydroxymethyl)-1-methyl-2-propynyl carbamate; (S)-1-(Hydroxymethyl)-1-methylprop-2-yn-1-yl carbamate; (S)-1-Methyl-1-(hydroxymethyl)propargyl carbamate; (1S)-1-Methyl-1-(hydroxymethyl)-2-propynyl carbamate; Chiral Propargyl Carbamate; (S)-Propargyl Alcohol Carbamate Derivative; Carbamic acid, (1-methyl-1-(hydroxymethyl)-2-propynyl)-, (S)-
EINECS	Contact for details

Quality Control

Our production of Carbamic Acid, [(1S)-1-(Hydroxymethyl)-1-Methyl-2-Propynyl]-, 1,1- adheres to stringent quality protocols to ensure batch-to-batch consistency and high chiral purity. Products undergo rigorous analytical testing, including chiral HPLC, to confirm identity, purity, and enantiomeric excess. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with each shipment. Our quality management system is designed to support cGMP compliance for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.