Description

3-(Difluoromethoxy)Bromobenzene is a high-purity fluorinated aromatic building block essential for advanced organic synthesis. This compound is valued for its unique difluoromethoxy and bromo substituents, which enable precise molecular modifications in complex chemical architectures. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and intermediates.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly in medicinal chemistry programs targeting CNS and metabolic diseases.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Serves as a fluorinated precursor in the synthesis of specialty materials for electronic displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromo substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on aromatic systems in academic and industrial R&D settings.
• Custom Synthesis & Contract Manufacturing: Employed by fine chemical manufacturers for the custom synthesis of complex, fluorinated molecules for client-specific projects.

Basic Information

Product Name	3-(Difluoromethoxy)Bromobenzene
CAS No.	262587-05-3
Molecular Formula	C7H5BrF2O
Molecular Weight	223.02 g/mol
Synonyms	1-Bromo-3-(difluoromethoxy)benzene; 3-Bromophenyl difluoromethyl ether; m-(Difluoromethoxy)bromobenzene; Bromo-3-(difluoromethoxy)benzene; Benzene, 1-bromo-3-(difluoromethoxy)-; 262587-05-3; 3-Bromo-alpha,α-difluoroanisole
EINECS	Contact for details

Quality Control

Our 3-(Difluoromethoxy)Bromobenzene is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including GC, HPLC, and NMR, to ensure identity, purity, and consistency. We provide full traceability and detailed Certificates of Analysis (COA) with each shipment. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most critical synthesis steps.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Purity (HPLC)	≥ 97.5%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.