Description

Fmoc-n-Methyl-Dl-Valine CAS NO 262361-60-4 is a protected, N-methylated derivative of the amino acid valine, featuring the fluorenylmethyloxycarbonyl (Fmoc) protecting group. This compound is a critical building block in modern solid-phase peptide synthesis (SPPS), enabling the controlled introduction of N-methylated valine residues to enhance peptide stability, bioavailability, and conformational diversity. It is primarily utilized by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers engaged in the development of therapeutic peptides, peptidomimetics, and complex organic molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the automated, stepwise synthesis of complex peptides, particularly those requiring N-methylated amino acids for improved metabolic stability.
• Pharmaceutical Research & Development: Used in the discovery and development of novel peptide-based therapeutics, including hormone analogs, enzyme inhibitors, and targeted drug delivery systems.
• Peptidomimetic Design: Facilitates the creation of peptide-like molecules with enhanced drug-like properties, such as increased membrane permeability and resistance to proteolytic degradation.
• Combinatorial Chemistry Libraries: Serves as a valuable component for generating diverse libraries of compounds for high-throughput screening against biological targets.
• Academic Research: Employed in biochemical and biophysical studies to investigate protein folding, structure-activity relationships (SAR), and molecular recognition processes.
• Fine Chemical Synthesis: Acts as a chiral synthon for the asymmetric synthesis of more complex, non-peptide organic molecules in advanced chemical manufacturing.

Basic Information

Product Name	Fmoc-n-Methyl-Dl-Valine
CAS No.	262361-60-4
Molecular Formula	C22H25NO4
Molecular Weight	367.44 g/mol
Synonyms	Fmoc-N-Me-DL-Val-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-N-methyl-DL-valine; N-Fmoc-N-methyl-DL-valine; (RS)-2-[(9H-Fluoren-9-ylmethoxy)carbonyl(methyl)amino]-3-methylbutanoic acid; Fmoc-N-methylvaline; N-Methyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]valine; DL-Fmoc-N-methylvaline
EINECS	Contact for details

Quality Control

Our Fmoc-n-Methyl-Dl-Valine is manufactured under strict quality control protocols to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. We adhere to industry best practices, and each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. Specifications are designed to meet the rigorous demands of pharmaceutical research and peptide synthesis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.