Description

2-Amino-2-(3,4,5-Trifluorophenyl)Acetic Acid is a high-value, non-proteinogenic amino acid derivative featuring a trifluoromethylphenyl side chain. This compound is a critical chiral building block in modern pharmaceutical synthesis, prized for its ability to impart metabolic stability and enhance the bioavailability of drug candidates. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and agrochemical industries for developing novel active ingredients.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and production of active pharmaceutical ingredients (APIs), particularly in protease inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Used in the development of advanced herbicides and pesticides, where the fluorine atoms contribute to biological activity and environmental persistence.
• Peptidomimetics Research: Serves as a foundational component in the design and synthesis of peptide analogs and mimetics for drug discovery programs.
• Ligand and Catalyst Development: Employed in the creation of specialized ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Studies: Acts as a standard or reagent in academic and industrial research focused on the unique properties of fluorinated organic compounds.

Basic Information

Product Name	2-Amino-2-(3,4,5-Trifluorophenyl)Acetic Acid
CAS No.	261952-27-6
Molecular Formula	C8H6F3NO2
Molecular Weight	211.13 g/mol
Synonyms	(3,4,5-Trifluorophenyl)glycine; 2-Amino-2-(3,4,5-trifluorophenyl)ethanoic acid; 3,4,5-Trifluoro-DL-phenylglycine; α-Amino-(3,4,5-trifluorophenyl)acetic acid; NSC 759108; (3,4,5-Trifluorophenyl)aminoacetic acid; DL-3,4,5-Trifluorophenylglycine
EINECS	Contact for details

Quality Control

Every batch of 2-Amino-2-(3,4,5-Trifluorophenyl)Acetic Acid is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the product meets the high-purity standards required for advanced synthetic applications. A detailed Certificate of Analysis (COA) including chiral purity, HPLC assay, and impurity profile is available for each lot upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee (Enantiomeric excess)
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Single Impurity (HPLC)	≤0.5%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.