Description

2-(Trifluoromethoxy)Anisole is a specialized fluorinated aromatic ether building block of significant interest in advanced organic synthesis. Its value lies in the unique combination of the electron-withdrawing trifluoromethoxy group and the methoxy substituent, which allows for precise modulation of electronic and steric properties in target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for creating novel active ingredients, as well as by manufacturers of liquid crystals and specialty materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of new drug candidates, particularly in medicinal chemistry programs targeting CNS disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the trifluoromethoxy group enhances biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a core or side-chain component in the synthesis of fluorinated liquid crystals for high-performance displays.
• Organic Electronics: Employed as a building block for electron-transport materials and semiconductors in OLEDs and organic photovoltaics.
• Specialty Polymer Modifier: Incorporated into polymer chains to impart specific properties like chemical resistance, thermal stability, or altered refractive index.
• Chemical Research & Development: A versatile reagent for method development and exploring new reactions in fluoroorganic chemistry.

Basic Information

Product Name	2-(Trifluoromethoxy)Anisole
CAS No.	261952-22-1
Molecular Formula	C8H7F3O2
Molecular Weight	192.14 g/mol
Synonyms	1-Methoxy-2-(trifluoromethoxy)benzene; 2-(Trifluoromethoxy)methoxybenzene; o-(Trifluoromethoxy)anisole; 2-Methoxyphenyl trifluoromethyl ether; Anisole, 2-(trifluoromethoxy)-; Benzene, 1-methoxy-2-(trifluoromethoxy)-
EINECS	Contact for details

Quality Control

Our 2-(Trifluoromethoxy)Anisole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including GC/HPLC for purity and identity confirmation via NMR and IR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. Certificates of Analysis (COA) with lot-specific data are provided to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from strong bases and fluorinating agents. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0% (Standard Grade)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.